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KMID : 0376319960080010065
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Dental Journal of CNU
1996 Volume.8 No. 1 p.65 ~ p.80
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The Effect of Static Magnetic Fields on Molecular and Cellular Activities
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Park Je-Koo
Hwang Hye-Nam
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Abstract
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Optimal force for orthodontic treatment is the force that produces a rapid rate of tooth movement without discomfort to the patient or ensuing tissue damage. Recently considerable interest has been generated in the application of magnets as a way to obtain an optimal force. In vitro assays were made for investigating the effect of static magnetic fields of Sm-Co magnets on molecular and cellular activities.
The distance of erythrocyte sedimentation was measured directly, and the activities and the syntheses of Fe^2+ -related enzymes (catalase and No synthase) and non Fe^2+ -related enzyme (lactic dehydrogenase) were assayed by the spectrophotometer. The growth and the proliferation of osteoblast-like cells MC_3 T_3-E_1 were determined by the crystal violet staining and the ^3H-thymidine incorporation. The erythrocytes were exposed to the pole face flux density of 1,400 G (gauss), and the enzymes and osteoblast-like cells MC_3 T_3 E_1 were exposed to the flux density of 7,000 G.
The results obtained were as follows :
1. The distance of sedimentation of erythrocyte was not affected by the static magnetic fields.
2. The activities of catalase and lactic dehydrogenase were not affected by the static magnetic fields.
3. The intracellular syntheses of NO synthase and lactic dehydrogenase were not affected by the static magnetic fields.
4. The growth and the proliferation of cultured osteoblast-like cells MC_3 T_3-E_1 were not affected by the static magnetic fields.
These results suggested that the molecular and cellular activities were not significantly influenced by the static magnetic fields.
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